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In our review, we ended up in a position to appreciably escalate the dose of CX-5461 past that achieved in the main-in-human examine in people with hematologic cancers. The RP2D of 475 mg/m2 on times one, 8, and 15 of the four-7 days cycle, was determined by phototoxicity, which happened Irrespective of stringent UV gentle avoidance protocols and